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Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain
- Source :
-
Brain Research . Oct2005, Vol. 1060 Issue 1/2, p188-192. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: Ethyl pyruvate (EP) is a pyruvate derivative, and has recently been reported to prevent lethality in mice with established lethal sepsis and systemic inflammation. In a previous study, we reported that EP has a neuroprotective effect in a rat cerebral ischemia model of middle cerebral artery occlusion (MCAO), in which it was found to be effective when injected as late as 12 h after MCAO/reperfusion. In the present study, we show that therapeutic window of pyruvate in this MCAO animal model is limited to 1 h (30 min before and 30 min after MCAO). Moreover, both pyruvate and EP have a neuroprotective effect during oxygen-glucose deprivation (OGD) or H2O2 challenge in primary cortical culture. In contrast, EP suppressed the LPS-induced activation of primary microglia in culture, but pyruvate did not. The suppression of microglia activation was evidenced by a reduction in nitric oxide release and by a proinflammatory factor induction in primary microglia culture, which were accompanied by the repression of nuclear factor-κB activation. These results suggest that EP has a strong protective effect and a wide therapeutic window, and that this protective effect of EP is related to its anti-inflammatory action. [Copyright &y& Elsevier]
- Subjects :
- *PYRUVATES
*ISCHEMIA
*BLOOD circulation disorders
*NEUROGLIA
Subjects
Details
- Language :
- English
- ISSN :
- 00068993
- Volume :
- 1060
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Brain Research
- Publication Type :
- Academic Journal
- Accession number :
- 18952258
- Full Text :
- https://doi.org/10.1016/j.brainres.2005.08.029