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Mapping by admixture linkage disequilibrium: advances, limitations and guidelines.
- Source :
-
Nature Reviews Genetics . Aug2005, Vol. 6 Issue 8, p623-633. 11p. 1 Diagram, 2 Charts, 3 Graphs. - Publication Year :
- 2005
-
Abstract
- Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200–500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14710056
- Volume :
- 6
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Nature Reviews Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 18892729
- Full Text :
- https://doi.org/10.1038/nrg1657