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High prevalence of hepatitis B, C and delta virus infections among blood donors in Mongolia.
- Source :
-
Archives of Virology . Dec2005, Vol. 150 Issue 12, p2513-2528. 16p. 1 Diagram, 5 Charts. - Publication Year :
- 2005
-
Abstract
- Serum samples obtained from 289 first-time and 114 repeat donors at the Blood Center of Mongolia (MBC) were tested for serological and molecular markers of hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) infections. Among the 403 blood donors, 33 (8.2%), 21 (5.2%), and 27 (6.7%) tested positive for hepatitis B surface antigen (HBsAg) and/or HBV DNA, HCV RNA, and HDV RNA, respectively. Collectively, 55 donors were viremic for one or more of these viruses, and included 54 first-time donors (18.7%) and 1 repeat donor (0.9%) ( P < 0.0001). One discrepant case with HBsAg detectable only at MBC was negative for HBsAg, HBV DNA and anti-HBc in this study. Four donors who were HCV-viremic in this study were negative for anti-HCV by the MBC method. Further efforts to increase the sensitivity and specificity of the currently-used tests are urgently required in Mongolia. Three donors who were positive for anti-HBc and anti-HDV but negative for HBsAg, had both HBV DNA and HDV RNA. This suggests that introduction of a new anti-HDV serological test is useful for not only HDV screening but also HBV screening of anti-HBc-positive, HBsAg negative donors, considering a possibility of viral interference by coexisting HDV. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD donors
*HEPATITIS B
*HEPATITIS C
*VIRAL hepatitis
Subjects
Details
- Language :
- English
- ISSN :
- 03048608
- Volume :
- 150
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Archives of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 18856010
- Full Text :
- https://doi.org/10.1007/s00705-005-0590-1