Total synthesis of hirsutellide A

Authors :: Xu, Yanjie
Chen, Ligong
Duan, Xuemin
Meng, Yi
Jiang, Liqin
Li, Meiling
Zhao, Guangle
Li, Yang
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2005, Vol. 46 Issue 25, p4377-4379. 3p.
Publication Year :: 2005
Abstract: Abstract: The total synthesis of hirsutellide A 1 was described. The linear hexadepsipeptide precursor 2 was synthesized in 45% yield from N-Boc-Me-Gly by three coupling reactions with DCC, HATU and BOP–Cl, respectively. Macrocyclization was successfully performed on the fully deprotected amino acid 14 with BOP–Cl in 15% yield and with FDDP in 22% yield. [Copyright &y& Elsevier]

Subjects :: *AMINO acids
*ORGANIC acids
*ORGANIC compounds
*CHEMICAL reactions

Language :: English
ISSN :: 00404039
Volume :: 46
Issue :: 25
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 18486954
Full Text :: https://doi.org/10.1016/j.tetlet.2005.04.087