Back to Search Start Over

Contemporary Incidence of Cognitive Impairment or Dementia in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis.

Authors :
Lo, Hui Zhen
Wee, Caitlin Fern
Low, Chen Ee
Teo, Yao Hao
Teo, Yao Neng
Yun, Choi Ying
Syn, Nicholas L.
Tan, Benjamin Y.Q.
Chai, Ping
Yeo, Leonard L.L.
Yeo, Tiong-Cheng
Chong, Yao Feng
Poh, Kian-Keong
Kong, William K.F.
Wong, Raymond C.C.
Chan, Mark Y.
Sia, Ching-Hui
Source :
Dementia & Geriatric Cognitive Disorders. 2025, Vol. 54 Issue 1, p52-66. 15p.
Publication Year :
2025

Abstract

Introduction: Despite the high prevalence of cognitive impairment or dementia post-coronary artery bypass grafting (CABG), the incidence of cognitive impairment or dementia post-CABG in contemporary practice is currently unclear. Therefore, this paper aims to investigate the incidence and associated risk factors of cognitive impairment or dementia in patients' post-CABG. Methods: A systematic search across three databases (PubMed, SCOPUS, and Embase) was conducted for studies published in or after 2013 that reported cognitive impairment or dementia post-CABG. Subgroup analyses and meta-regression by risk factors were performed to determine their influence on the results. Results: This analysis included 23 studies with a total of 2,620 patients. The incidence of cognitive impairment or dementia less than 1 month, 2 to 6 months, and more than 12 months post-CABG was 35.96% (95% confidence interval [CI]: 28.22–44.51, I2 = 87%), 21.33% (95% CI: 13.44–32.15, I2 = 88%), and 39.13% (95% CI: 21.72–58.84, I2 = 84%), respectively. Meta-regression revealed that studies with more than 80% of the cohort diagnosed with hypertension were significantly associated with incidence of cognitive impairment or dementia less than 1 month post-CABG. Conclusion: This meta-analysis demonstrates a high incidence of cognitive impairment or dementia in patients' post-CABG in contemporary practice, particularly less than 1 month post-CABG and more than 12 months post-CABG. We found that hypertension was a significant risk factor in the short-term (less than 1 month) follow-up period for cognitive impairment or dementia post-CABG. Future research should be done to assess strategies to reduce cognitive impairment post-CABG. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14208008
Volume :
54
Issue :
1
Database :
Academic Search Index
Journal :
Dementia & Geriatric Cognitive Disorders
Publication Type :
Academic Journal
Accession number :
182846999
Full Text :
https://doi.org/10.1159/000540450