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Effect of chondroitin sulfate and hyaluronic acid on gene expression in a three-dimensional culture of chondrocytes
- Source :
-
Journal of Bioscience & Bioengineering . Jul2005, Vol. 100 Issue 1, p123-126. 4p. - Publication Year :
- 2005
-
Abstract
- The effect of glycosaminoglycan addition on a three-dimensional (3D) culture of porcine chondrocyte cells was investigated with a view to use in cartilage regenerative medicine. Chondroitin sulfate C increased the mRNA expression of type 2 collagen, while chondroitin sulfate A did not. Hyaluronic acid of high molecular weight markedly decreased the mRNA expression of both aggrecan and type 2 collagen, although hyaluronic acid of low molecular weight showed no apparent effect. [Copyright &y& Elsevier]
- Subjects :
- *GLYCOSAMINOGLYCANS
*CARTILAGE
*COLLAGEN
*PORCINE somatotropin
*CARTILAGE cells
Subjects
Details
- Language :
- English
- ISSN :
- 13891723
- Volume :
- 100
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Bioscience & Bioengineering
- Publication Type :
- Academic Journal
- Accession number :
- 18273958
- Full Text :
- https://doi.org/10.1263/jbb.100.123