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Treatment for psychological dependence on morphine: Usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens
- Source :
-
Life Sciences . Sep2005, Vol. 77 Issue 18, p2207-2220. 14p. - Publication Year :
- 2005
-
Abstract
- Abstract: A growing body of evidence indicates that the mesolimbic dopaminergic (DAergic) pathway projecting from the ventral tegmental area (VTA) to the nucleus accumbens (N.Acc.) play a critical role in the initiation of psychological dependence on morphine. As well as DAergic system, the involvement of non-DAergic neurotransmitter and neuromodulator systems in rewarding effects induced by morphine has been recently documented. We previously demonstrated that the morphine-induced rewarding effect was dramatically suppressed by co-treatment with NMDA receptor antagonists, such as dizocilpine (MK-801), ketamine and ifenprodil. Therefore, we propose here that inhibiting the N-methyl-d-aspartate (NMDA) receptor and its associated protein kinase in the N.Acc. is useful for the treatment for psychological dependence on morphine. The following review provides a summary of recent our findings regarding the role of NMDA receptor and its associated protein kinase in the development of psychological dependence on morphine. [Copyright &y& Elsevier]
- Subjects :
- *PROTEIN kinases
*MORPHINE
*METHYL aspartate
*KETAMINE
Subjects
Details
- Language :
- English
- ISSN :
- 00243205
- Volume :
- 77
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 18236028
- Full Text :
- https://doi.org/10.1016/j.lfs.2005.04.015