Evaluation of the Effect of Oral Pregabalin (150 Mg) Premedication in Attenuation of Hemodynamic Responses to Laryngoscopy and Intubation in Patients Undergoing General Anaesthesia.

Background: Laryngoscopy and endotracheal intubation are known to cause significant hemodynamic responses that can be detrimental in susceptible patients. This study evaluated the efficacy of oral pregabalin premedication in attenuating these responses. METHODS: In this prospective randomized double-blind controlled study, 120 ASA I-II patients aged 18-60 years undergoing elective surgeries were randomly allocated into two groups (n=60 each). Group A received oral pregabalin 150mg and Group B received placebo 90 minutes before induction. Standard anesthetic protocol was followed. Hemodynamic parameters were recorded at baseline, pre-induction, and at 1,2,4,6,8,10 and 15 minutes after intubation. Results: In Group A (Pregabalin), heart rate peaked at 1 minute (102.28±7.583 bpm) and returned to baseline by 6 minutes (88.53±9.335 bpm). Systolic blood pressure peaked at 2 minutes (122.30±5.762 mmHg) and normalized by 4 minutes (117.23±6.074 mmHg). Diastolic blood pressure and mean arterial pressure increased at 1 minute (86.47±8.087 and 97.97±6.580 mmHg respectively) and fell below baseline by 4 minutes. The magnitude of these changes was significantly lower than in Group B (p<0.01). Control group showed persistently elevated parameters even at 15 minutes post-intubation. Conclusion: Oral pregabalin 150mg administered 90 minutes before induction effectively attenuates the hemodynamic stress response to laryngoscopy and intubation without significant adverse effects. [ABSTRACT FROM AUTHOR]