动物双歧杆菌乳亚种 SF 联合植物乳杆菌 1201 对 非酒精性脂肪肝的缓解作用.

To study the effect of probiotics on diet-induced non-alcoholic fatty liver disease (NAFLD) in mice, the NAFLD mouse model was established by giving NAFLD model diet, simultaneously, with 100 µL probiotic mixture (Lactobacillus plantarum 1201 and Bifidobacterium animalis subsp. lactis SF) intervention by gavage for 12 weeks. The results showed that the combined intervention recovered liver function, alleviated oxidative stress, and regulated autophagy in NAFLD mice; significantly improved intestinal flora and reduced endotoxin production, thereby inhibited the LPS/NF-κB signaling pathway and alleviated the inflammatory response. In addition, the combined dual bacterial intervention also improved insulin resistance in mice and regulated the PI3K-Akt/AMPK signaling pathway, which in turn regulated lipid metabolism, thereby reduced lipid accumulation in the liver. [ABSTRACT FROM AUTHOR]