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Involvement of 5-lipoxygenase in spinal cord injury
- Source :
-
Journal of Neuroimmunology . Sep2005, Vol. 166 Issue 1/2, p55-64. 10p. - Publication Year :
- 2005
-
Abstract
- Abstract: A traumatic spinal cord injury (SCI) induces a sequelae of events which conduce biochemical and cellular alterations. Here we compare the degree of spinal cord injury caused by the application of vascular clips, in mice lacking the 5-lipoxygenase and in the corresponding wild-type mice. Biochemical, immunohistochemical and functional studies revealed respectively an increase of neutrophils infiltration, of IL-1β, TNF-α immunoreactivity, apoptosis (measured by Annexin-V staining) and loss of hind legs movement in SCI operated 5-LO wild-type mice. In contrast, the degree of (1) neutrophil infiltration at different time points, (2) cytokine expression (TNF-α and IL-1β), (3) histological damage, (4) apoptosis, was markedly reduced in the tissues obtained from SCI operated 5-LO deficient mice and (5) the motor recovery was ameliorated. [Copyright &y& Elsevier]
- Subjects :
- *LIPOXYGENASES
*OXYGENASES
*IMMUNOREGULATION
*CENTRAL nervous system
Subjects
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 166
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 18221602
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2005.05.009