Synthesis, cytotoxicity and molecular docking study of novel acid amine coupling derivatives.

A library of novel acid amine coupling products was synthesized and the components tested for their in vitro cytotoxicity against human breast cancer cell lines viz. MCF-7 and MDA-MB-231. One of the compounds displayed superior activity against both cell lines, with lower IC50 values compared to standard reference Doxorubicin. Two other compounds showed promising activities with encouraging IC50 values against MCF-7, and MDA-MB-231. A molecular docking study of these molecules against EGFR gave their docking scores and binding interactions, and predicted their ADME properties. [ABSTRACT FROM AUTHOR]