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Assessment of OTR measurement techniques in the bubble environment of an industrial fermenter.

Assessment of OTR measurement techniques in the bubble environment of an industrial fermenter.

Authors :
Mikushin, Pavel
Starodumov, Ilya
Shuvaev, Alexander
Lezhnin, Sergey
Makhaeva, Ksenia
Chernushkin, Dmitrii
Zagoruiko, Andrey
Minakov, Denis
Nizovtseva, Irina
Source :
European Physical Journal: Special Topics. Dec2024, Vol. 233 Issue 23, p3519-3534. 16p.
Publication Year :
2024

Abstract

A comprehensive assessment of oxygen transfer rate (OTR) measurement techniques in the bubble environment of large-scale industrial fermenters is presented. Specifically, we focus on the sodium sulfite and hydrogen peroxide methods, two of the most commonly used approaches for measuring OTR in high oxygen-demand systems, and compare them with the nitrogen degassing method. A theoretical review of these methods is conducted and supplemented with experimental data collected from a 5-l stirred-tank fermenter. Through this comparative analysis, the key differences between the methods are highlighted, including the enhancement factor effect, their applicability to industrial bioreactors with high volumetric mass transfer coefficients ( k L a ), and the challenges associated with scaling these techniques to industrial systems. Results underscore the critical role of OTR in determining mass transfer efficiency in aerobic bioreactors, while also outlining the relationship of OTR to biochemical reactions in the environment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19516355
Volume :
233
Issue :
23
Database :
Academic Search Index
Journal :
European Physical Journal: Special Topics
Publication Type :
Academic Journal
Accession number :
182152063
Full Text :
https://doi.org/10.1140/epjs/s11734-024-01378-x