心力衰竭患者血清 8-OHdG、NT-proBNP、MnSOD 水平的变化及其与认知功能的相关性.

Objective To investigate the changes of serum 8-hydroxy-2′-deoxyguanosine ( 8-OHdG), NTproBNP and manganese superoxide dismutase (MnSOD) in patients with heart failure (HF), and their correlation with cognitive function. Methods Ninety-six patients with HF were prospectively selected as reserach objects (HF group), meanwhile, another 96 healthy physical examinees were also enrolled as the control group. The cognitive function of the HF patients was assessed by the Montreal cognitive assessment (MoCA) score. The serum levels of 8-OHdG, NT-proBNP and MnSOD were compared between the two groups, and patients with different cognitive status at admission. The correlation between the levels of the above three serum markers and MoCA score was also analyzed. The diagnostic value of the above three serum indicators for cognitive dysfunction at admission was analyzed. Results The levels of serum 8-OHdG and NT-proBNP in patients with HF at admission were significantly higher than those in the control group, while the level of serum MnSOD was significantly lower (all P<0. 01). The levels of serum 8-OHdG and NT-proBNP in HF patients with cognitive dysfunction were significantly higher than those in HF patients with normal cognition funtion, while the level of serum MnSOD was significantly lower (all P< 0. 01). For the HF patients at admission, the levels of serum 8-OHdG and NT-proBNP were both positively correlated with the MoCA score, while the level of serum MnSOD was negatively correlated with the MoCA score (all P<0. 05). In the diagnosis of cognitive dysfunction among HF patients, the area under the curve, sensitivity, and specificity of the combination of serum 8-OHdG, NT-proBNP, and MnSOD levels at admission were all significantly higher than those by using any single of the three indicators. Conclusion The serum levels of 8-OHdG, NT-proBNP and MnSOD are closely related to complicated cognitive dysfunction in patients with HF. The joint detection of the three markers significantly increases the diagnostic value of cognitive dysfunction in HF patients, which could provide references for clinical treatment. [ABSTRACT FROM AUTHOR]