Exosomes and machine perfusion as a therapy to improve organ transplantation.

The article discusses the use of exosomes and machine perfusion as a therapy to improve organ transplantation outcomes. Exosomes, small extracellular vesicles, play a unique role in cellular communication and can be used to reduce ischemia/reperfusion injury in transplanted organs. Studies have shown that exosomes derived from various cell types, including urine progenitor cells, have anti-inflammatory and regenerative properties that can enhance organ preservation and resuscitation methods. While exosome-based therapies show promise in improving transplant outcomes, further research is needed to standardize isolation methods and identify specific bioactive molecules for targeted modifications. [Extracted from the article]