Remissão de Calcinose cutânea em cão após tratamento de Hipercortisolismo ACTH-Dependente.

Cutaneous calcinosis in dogs is a dermatological alteration caused by the excessive deposition of calcium salts in the skin, resulting in discomfort and aesthetic changes. Hypercortisolism, characterized by an excess of cortisol due to an imbalance in the HPA axis, is one of the main causes of the disease, leading to metabolic changes that favor calcium deposition in the skin. Symptoms include hard subcutaneous nodules, often ulcerative, as well as pruritus and local inflammation. Diagnosis is made based on clinical exams, cytology, biopsies, and laboratory analyses. Treatment aims to control the primary disease and, in severe cases, surgical removal of the nodules. A 10-year-old dog was referred for endocrinological and dermatological evaluation due to diffuse lesions on the back, symptoms of polyuria, polydipsia, increased appetite, and muscle weakness. The animal was already receiving chronic treatment with oral glucocorticoids and topical ointment due to allergic dermatitis. Given the suspicion of hypercortisolism, abdominal ultrasonography, complete blood count, biochemistry, and dexamethasone suppression test were performed, revealing dyslipidemia, increased ALT and phosphatase, reduced urine density, and enlarged adrenal glands on ultrasonography. After temporary discontinuation of glucocorticoids, new tests confirmed hypercortisolism, corroborated by suppression tests and urinary cortisol/creatinine ratio after 30 days without corticosteroids. Skin cytology ruled out significant infections and inflammations. Histopathological examination of the lesion confirmed cutaneous calcinosis. The initiated treatment included mupirocin + DMSO lotion for the lesions and oral trilostane to control hypercortisolism, resulting in significant improvement in the clinical condition after 30 days. [ABSTRACT FROM AUTHOR]