加味芍甘附子汤联合温和灸对寒湿痹阻型活动期类风湿关节炎患者 免疫功能和血清 IL-1茁、IL-6、IL-18 的影响.

Objective: To observe the combined treatment of jiawei shaogan fuzi decoction and mild moxibustion in patients with active rheumatoid arthritis (RA) of cold-dampness obstruction type, the effects on immune function and serum interleukin (IL)-1β, IL-6, IL-18. Methods: 142 patients with active RA (cold-dampness obstruction type) were divided into control group (mild moxibustion treatment, n=71) and combine group (Jiawei Shaogan Fuzi Decoction combine with mild moxibustion treatment, n=71) according to the ran- dom number table method. The efficacy, laboratory indexes, immune function and serum inflammatory factors were compared between two groups. Results: Compared with control group, the total clinical effective rate in combine group was significantly higher (P<0.05). Compared with control group after treatment, rheumatoid factor (RF), erythrocyte sedimentation rate(ESR), C-reactive protein (CRP), immunoglobulin G(IgG), immunoglobulin G(IgA), immunoglobulin M(IgM), IL-1β, IL-6 and IL-18 in combine group were lower (P<0.05). Conclusion: Jiawei shaogan fuzi decoction combined with mild moxibustion can improve clinical treatment effect, regulate immune func- tion and inhibit serum IL-1β, IL-6 and IL-18 levels in patients with active RA of cold-dampness obstruction type. [ABSTRACT FROM AUTHOR]