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The effect of preconditioning on the Cu, Zn superoxide dismutase expression and enzyme activity in rat brain at the early period after severe hypobaric hypoxia
- Source :
-
Neuroscience Research . Sep2005, Vol. 53 Issue 1, p39-47. 9p. - Publication Year :
- 2005
-
Abstract
- Abstract: Severe hypoxia results in functional and structural injury of the brain. A preconditioning with repetitive episodes of mild hypoxia considerably ameliorates neuronal resistance to subsequent severe hypoxia. Activation of endogenous antioxidants including Cu, Zn-depending superoxide dismutase (Cu, Zn-SOD) (EC.1.15.1.1) is one of the main cell defense mechanisms against oxidative stress induced by hypoxia. Alterations of expression and enzyme activity of Cu, Zn-SOD 3 and 24h after severe hypobaric hypoxia in forebrain structures of preconditioned and non-preconditioned rats were investigated. We found that hypoxia without preconditioning suppressed the Cu, Zn-SOD enzyme activity at 3h time-point but preconditioning essentially modified the reaction to severe hypoxia by increasing the expression and activity of Cu, Zn-SOD during early stages of reoxygenation crucial for apoptosis initiation. [Copyright &y& Elsevier]
- Subjects :
- *CEREBRAL anoxia
*BRAIN injuries
*CHEMICAL inhibitors
*OXIDATIVE stress
Subjects
Details
- Language :
- English
- ISSN :
- 01680102
- Volume :
- 53
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neuroscience Research
- Publication Type :
- Academic Journal
- Accession number :
- 18160804
- Full Text :
- https://doi.org/10.1016/j.neures.2005.05.010