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Janus PES-based architectures integrated dense membrane with porous monolith for simultaneous plasma separation and toxins adsorption.

Authors :
Yin, Hongyu
Wang, Zhoujun
Zhang, Xiang
Zhao, Weifeng
Wei, Ran
Zhao, Changsheng
Source :
Chemical Engineering Journal. Dec2024, Vol. 502, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

[Display omitted] • The Janus architecture integrates dense membrane with porous monolith. • The monolith with multi-scale porous structure is fabricated by FIPS technique. • The monolith shows excellent removal effect of small and medium molecular toxins. • The Janus architecture can block blood cells while allow over 85% BSA to permeate. • The Janus architecture achieves simultaneous plasma separation and adsorption. Chronic liver failure (CLF) and chronic renal failure (CRF) lead to toxins accumulation, severely impairing organ functions. To address this challenge, a Janus polyethersulfone (PES)-based architecture integrated dense membrane with porous monolith is developed, pioneering an approach for simultaneous plasma separation and toxins adsorption. The porous monolith, featuring high porosity about 83.3 % and substantial specific surface area about 102.06 m2/g, is prepared using the freezing-induced phase separation (FIPS) technique. The porous monolith is composed of polymer networks of PES and amphiphilic copolymer of poly (vinyl pyrrolidone-co-methyl methacrylate) (VM), as well as activated carbon. Among the various monolith, the PES 18 VM 5 C 2 exhibits the optimal balance of adsorption and anti-protein adhesion. The PES-VM-incorporated dense membrane with a controlled submicron pore size is constructed atop the PES 18 VM 5 C 2. The dense membrane effectively blocks hemocytes and the porous monolith efficiently adsorbs toxins. Together, the Janus architecture PES 18 VM 5 C 2 @M 16 allows over 85 % of bovine serum albumin (BSA) to permeate, showcasing its selective permeability. After being integrated into a custom 3D-printed supporting device, the PES 18 VM 5 C 2 @M 16 achieves significant clearance in creatinine (67.6 %), uric acid (87.4 %), and bilirubin (89.1 %) during 2-hour plasma adsorption test, with minimal impact on essential plasma components such as total protein, albumin, and cholesterol. This work presents a "Janus Interface Architecture" as next-generation platform for plasma separation and toxins adsorption, offering a promising strategy for wearable artificial liver systems. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13858947
Volume :
502
Database :
Academic Search Index
Journal :
Chemical Engineering Journal
Publication Type :
Academic Journal
Accession number :
181603297
Full Text :
https://doi.org/10.1016/j.cej.2024.157944