PEG-PCL 载姜黄素胶束的构建及其评价.

Curcumin (CUR) is extracted from the dried rhizome of Curcuma longa. It is cost-effective and easily accessible, exhibiting vibrant hues. Moreover, it encompasses a wide range of activities including anti-inflammatory, antioxidant, and anticancer properties. However, the application of CUR is constrained by its limited water solubility and low bioavailability. The amphiphilic copolymer poly (ethylene glycol) -b-poly (ε-caprolactone) (PEG-PCL) was employed for the preparation of micelles to solve these issues. The formation mechanism, drug loading performance, stability, release and cellular uptake of PEG-PCL micelles were comprehensively evaluated. A series of micelles based on PEG-PCL with different molecular weights(PEG2K-PCL3.5K, PEG2K-PCL5K, PEG5K-PCL3K,PEG5K-PCL5K, PEG5K-PCL13K) showed high encapsulation efficiency. The encapsulation efficiency of PEG2K-PCL5K reached 98.38±3.06%, demonstrating high efficacy in encapsulation. The encapsulation of PEG-PCL significantly enhanced the dissolution rate of CUR and exhibited a sustained release effect, concurrently augmenting the antioxidant capacity of CUR. The micelles exhibit a transparent appearance, demonstrating excellent stability, and they can be re-dispersed in water after freeze-drying. PEG-PCL micelles demonstrated the excellent biocompatibility and could be internalized by enterocyte. Meanwhile, the molecular weight of PEG-PCL was correlated with the particle size, encapsulation efficiency, drug loading performance, and cellular uptake efficiency of micelles. In summary, the utilization of PEG-PCL micelles enhanced the solubility, stability, and cellular uptake of CUR, there by offering potential strategies for the efficient delivery of hydrophobic bioactive molecules. [ABSTRACT FROM AUTHOR]