Comment.

Presents the authors' comments on the paper "Semilinear High-Dimensional Model for Normalization of Microarray Data: A Theoretical Analysis and Partial Consistency," by Jianqing Fan, Heng Peng, and Tao Huang, published in the September 2005 issue of the "Journal of the American Statistical Association." Congratulations to the authors for their interesting, innovative, and important contribution on microarray normalization; Analysis of the main contributions made by the authors; Suggestions for some possible extensions to the results of the authors; Views on the goal of significance analysis; Appreciation of the paper for its computational simplicity.