Comment.

Presents the author's comments on the paper "Semilinear High-Dimensional Model for Normalization of Microarray Data: A Theoretical Analysis and Partial Consistency," by Jianqing Fan, Heng Peng and Tao Huang, published in the September 2005 issue of the "Journal of the American Statistical Association." Appreciation of the authors for their significant contribution in enlarging the bag of statistical tools available for normalization; Opinion on the normalization strategy described; Importance of the iterative procedure suggested; Views on the focus of the paper from a methodological standpoint; Contexts in which the methodology described may be applicable.