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Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice.

Authors :
Chen, Yumin
Bai, Xue
Zhang, Ying
Zhao, Yafang
Ma, Huagen
Yang, Yunbo
Wang, Meijun
Guo, Yinghui
Li, Xiaopeng
Wu, Tong
Zhang, Yue
Kong, Hui
Zhao, Yan
Qu, Huaihua
Source :
Artificial Cells, Nanomedicine & Biotechnology. Dec2024, Vol. 52 Issue 1, p12-22. 11p.
Publication Year :
2024

Abstract

Chinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical carbon nanostructures ranging from 0.97 to 2.3 nm in diameter, with fluorescent properties and a surface rich in functional groups. We further investigated the impact of ZR-CDs on oestradiol and FSH in serum, growth, and the development of ovarian and uterine using normal female mice and exogenous oestradiol intervention model. It was observed that ZR-CDs accelerated oestrogen metabolism and attenuated oestradiol-induced endometrial hyperplasia. Simultaneously, ZR-CDs triggered an increase in FSH, even in the presence of high-serum oestradiol that inhibits FSH secretion. Our findings suggest that ZR-CDs could be a potential therapeutic treatment for anovulatory menstruation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
21691401
Volume :
52
Issue :
1
Database :
Academic Search Index
Journal :
Artificial Cells, Nanomedicine & Biotechnology
Publication Type :
Academic Journal
Accession number :
181482323
Full Text :
https://doi.org/10.1080/21691401.2023.2276770