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CpG motif in ATCGAT hexamer improves DNA-vaccine efficiency against lethal Pseudorabies virus infection in pigs
- Source :
-
Vaccine . Aug2005, Vol. 23 Issue 36, p4532-4540. 9p. - Publication Year :
- 2005
-
Abstract
- Abstract: This study evaluated the adjuvant activity of a porcine-specific type A CpG-containing oligodeoxynucleotide (CpG-ODN) in a DNA-vaccine against Pseudorabies virus (PrV) infection. This vaccine, composed of three independent plasmids encoding PrV gB, gC and gD glycoproteins, was injected alone or was co-injected with CpG-ODN or control GpC-ODN. CpG-ODN improved the PrV-specific humoral immune response and provided better clinical protection against lethal PrV-infection. The PrV-specific cell-mediated immune response seemed also to be increased. [Copyright &y& Elsevier]
- Subjects :
- *VIRUS diseases
*IMMUNOLOGICAL adjuvants
*PREVENTIVE medicine
*VACCINATION
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 23
- Issue :
- 36
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 18137136
- Full Text :
- https://doi.org/10.1016/j.vaccine.2005.03.046