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Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Aug2005, Vol. 15 Issue 15, p3580-3583. 4p. - Publication Year :
- 2005
-
Abstract
- Abstract: Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (−)-2,3-O-isopropylidene-d-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps. [Copyright &y& Elsevier]
- Subjects :
- *NEOVASCULARIZATION
*CELL division
*CELL proliferation
*CELL growth
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 18126426
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.05.065