Toxicity and Sublethal Effect of Chlorantraniliprole on Multiple Generations of Aedes aegypti L. (Diptera: Culicidae).

Simple Summary: Mosquitoes are vectors of various diseases in humans. Due to the quick development of insecticide resistance, it is crucial to optimize management programs by understanding the sublethal effects of effective insecticides like chlorantraniliprole on Aedes aegypti L. populations. For this purpose, a population of Ae. aegypti was reared in the laboratory for 15 generations then exposed to chlorantraniliprole and sublethal effects were studied on F1 and F2 generations. The following life history parameters were decreased significantly in exposed F1 and F2 generations compared to the control: larval duration, male longevity, female longevity, and oviposition days. The adult preoviposition and total preoviposition period did not differ significantly. The fecundity of Ae. aegypti in F1 generation decreased from 61 eggs/female in the control to 34 eggs/female in LC50. In conclusion, our findings demonstrate that sublethal doses of chlorantraniliprole have significant transgenerational effects on Ae. aegypti mosquitoes. The cautious usage of chlorantraniliprole is recommended for the effective management of mosquitoes and to lessen long-term influence on human health and the environment. Due to the quick development of insecticide resistance, it is crucial to optimize management programs by understanding the sublethal effects of effective insecticides like chlorantraniliprole on Aedes aegypti L. populations. Using age-stage and two-sex life tables, we investigated the sublethal impacts of chlorantraniliprole on Ae. aegypti. Larval duration in the progeny of exposed parents was reduced by 0.33–0.42 days, whereas, the longevity of male and female adults was decreased by 1.43–3.05 days. Similarly, the egg-laying capacity of F1 and F2 progeny of the exposed parents was significantly reduced from 27.3% to 41.2%. The mean generation time (T) increased up to 11.8% in exposed populations, and the net reproduction rate (Ro) decreased by 51.50–55.60%. After 24 h of chlorantraniliprole treatment, there was a significant increase in cytochrome P450 activity. Contrarily, the activity of glutathione S-transferase (GST) initially declined but started increasing after 48 h of treatment. This research highlights the importance of chlorantraniliprole in mosquito management, as well as the importance of considering sublethal effects when developing strategies to handle them. Having a thorough understanding of the harmful effects of insecticides on mosquito populations can greatly enhance the effectiveness of insecticide-based interventions, while also minimizing the risk of pest resurgence. [ABSTRACT FROM AUTHOR]