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Pacritinib and concurrent azole antifungal therapy is deliverable in patients with hematologic malignancies.

Pacritinib and concurrent azole antifungal therapy is deliverable in patients with hematologic malignancies.

Authors :
Trang, Dina
Ngo, Dat
Ali, Haris
Tinajero, Jose
Source :
Journal of Oncology Pharmacy Practice. Dec2024, Vol. 30 Issue 8, p1437-1441. 5p.
Publication Year :
2024

Abstract

Objective: Pacritinib is a novel kinase inhibitor approved for the treatment of adults with intermediate or high-risk primary or secondary myelofibrosis. Strong and moderate CYP3A4 inhibitors, such as some azole antifungals, are contraindicated or recommended to be avoided in combination with pacritinib, respectively. We aim to report our experience in patients who received pacritinib with concurrent azole antifungal therapy. Data Sources: We queried for patients with hematologic malignancies in the electronic medical record who received concurrent pacritinib and azole antifungal therapy. Data Summary: There were five cases of concurrent pacritinib and azole antifungal therapy in which none of the patients experienced grade 3 or higher non-hematologic toxicities. Some patients required dose modifications and/or interruptions in pacritinib therapy. Conclusion: This is the first clinical experience describing concurrent pacritinib and azole antifungals. Our experience shows that in the setting where this interaction cannot be avoided, concurrent administration is feasible with close monitoring and possible empiric dose reductions in select patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10781552
Volume :
30
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Oncology Pharmacy Practice
Publication Type :
Academic Journal
Accession number :
181132134
Full Text :
https://doi.org/10.1177/10781552241275205