Manganese‐Mediated Cascade Radical Oxidative Cyclization/1,6‐Conjugate Addition of Unsaturated Oximes with p‐Quinone Methides: Facile Access to β,β‐Diarylmethine Substituted Isoxazolines.

A simple and efficient strategy for the synthesis of structurally diverse <italic>β</italic>,<italic>β</italic>‐diarylmethine substituted isoxazoline derivatives have been developed. This approach employs a manganese‐promoted oxidative cyclization coupled with a 1,6‐conjugate addition of unsaturated oximes to <italic>p</italic>‐quinone methides. The key features of this study include the formation of C−O and C−C bonds through intramolecular and intermolecular interactions, facilitated by <italic>in situ</italic> generated iminoxyl radicals. <italic>β</italic>,<italic>β</italic>‐diarylmethine substituted isoxazolines, bearing a wide range of functional groups, were isolated in high yields. [ABSTRACT FROM AUTHOR]