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Synthesis and Characterization of Copper‐Crosslinked Carbon Dot Nanoassemblies for Efficient Macrophage Manipulation.

Synthesis and Characterization of Copper‐Crosslinked Carbon Dot Nanoassemblies for Efficient Macrophage Manipulation.

Authors :
Girma, Wubshet Mekonnen
Zhu, Zewen
Guo, Yunqi
Xiao, Xianghao
Wang, Zhiqiang
Mekuria, Shewaye Lakew
Hameed, Meera Moydeen Abdul
EL‐Newehy, Mohamed
Guo, Rui
Shen, Mingwu
Shi, Xiangyang
Source :
Macromolecular Rapid Communications. Nov2024, Vol. 45 Issue 22, p1-9. 9p.
Publication Year :
2024

Abstract

Nanomedicines loaded in macrophages (MAs) can actively target tumors without dominantly relying on the enhanced permeability and retention (EPR) effect, making them effective for treating EPR‐deficient malignancies. Herein, copper‐crosslinked carbon dot clusters (CDCs) are synthesized with both photodynamic and chemodynamic functions to manipulate MAs, aiming to direct the MA‐mediated tumor targeting. First, green fluorescent CDs (g‐CDs) are prepared by a one‐step hydrothermal method. Subsequently, the g‐CDs are complexed with divalent copper ions to form copper‐crosslinked CDCs (g‐CDCs/Cu), which are incubated with MAs for their manipulation. Experimental results revealed that the prepared g‐CDCs/Cu displayed good aqueous dispersibility and fluorescent emission properties. The nanoassemblies can be activated to deplete the overexpressed glutathione (GSH) and generate reactive oxygen species (ROS) in the presence of laser irradiation through the combined Cu‐mediated chemodynamic therapy and CD‐mediated photodynamic therapy. Furthermore, the ROS produced in MAs enabled polarization of MAs to antitumor M1 phenotype, suggesting the future potential use to reverse the immunosuppressive tumor microenvironment. These results obtained from the current study suggest a significant potential to develop g‐CDCs/Cu for GSH depletion, ROS generation, and MA M1 polarization as a theransotic agent to tackle cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10221336
Volume :
45
Issue :
22
Database :
Academic Search Index
Journal :
Macromolecular Rapid Communications
Publication Type :
Academic Journal
Accession number :
181057871
Full Text :
https://doi.org/10.1002/marc.202400511