Effects of letrozole therapy in former users of anabolic steroids: A randomized clinical trial.

The article discusses a randomized clinical trial investigating the effects of letrozole therapy on serum testosterone, sperm quality, and withdrawal symptoms in former users of anabolic steroids with testosterone deficiency. The trial was terminated prematurely due to recruitment issues, but results showed that letrozole therapy increased serum testosterone levels and improved sperm quality and withdrawal symptoms. The study authors suggest that longer exposure to anabolic steroids among participants in the placebo group may have influenced the results, and caution that the findings should be considered exploratory. [Extracted from the article]