Simultaneous Voltammetric Determination of Kanamycin and Ampicillin Using an Ultrasensitive Electrochemical Nanosensor with Partial Least Squares (PLS) and Orthogonal Signal Correction (OSC-PLS)

AbstractA sensitive electrochemical nanosensor based on a glassy carbon electrode modified by carbon nanofibers (CNFs) was developed to simultaneously determine kanamycin and ampicillin. Under optimized conditions, the nanosensor showed a wide dynamic linear range (1.0 × 10−11-1.0 × 10−6 M and 1.0 × 10−10-1.0 × 10−6 M) and a low detection limit (6.12 × 10−12 M and 1.47 × 10−11 M) for kanamycin and ampicillin, respectively. The multivariable calibration of OSC-PLS was adopted to separate the obtained voltammograms. The root mean square error of prediction (RMSEPs) of kanamycin and ampicillin using the OSC-PLS model were 0.05 and 0.08, respectively. The method was used to simultaneously determine kanamycin and ampicillin in tap water. [ABSTRACT FROM AUTHOR]