不同年龄段流行性腮腺炎患儿发病特征、危险因素 及 T 淋巴细胞亚群、炎症因子与其相关性分析.

Objective: Explore the incidence characteristics, risk factors, T lymphocyte subsets, inflammatory factors, and their correlation in children with mumps of different age groups. Methods: 80 children with mumps who came to our hospital for diagnosis and treatment from January 2021 to December 2023 were selected as the observation group, and 160 children who underwent routine physical examinations during the same period were selected as the control group. According to age, the observation group and control group were divided into 2-6 year old group, 7-12 year old group, and>12 year old group. Analyze the incidence characteristics, risk factors, and correlation between T lymphocytes and inflammatory factors in children with mumps at different age groups. Results: School children, those who have received less than 2 doses of the vaccine, those who have not received the mumps vaccine, and migrant children are risk factors for mumps (P<0.05) The levels of CD3+, CD3 CD4+, and CD3 CD8+ in 7-year-old children were higher than those in 2-6 year old children (P<0.05); The CD3 CD4+ and CD3+CD4/CD3+CD8+ levels in the observation group were lower than those in the control group, while CD3 CD8 levels were higher than those in the control group (both P<0.05). CD3+, CD3 CD4+, CD3 CD8 in the observation group were positively correlated with CRP and TNF-a (all P<0.05). Conclusion: School children, those who have received less than 2 doses of the vaccine, those who have not received the mumps vaccine, and migrant children are risk factors for mumps. Changes in T lymphocyte subsets and inflammatory factors can impair immune function and increase the risk of infection, which requires close attention. [ABSTRACT FROM AUTHOR]