肺鳞状细胞癌组织 FOXA1、UCHL1 表达与临床病理参数和预后的关系.

Objective: To investigate the relationship between the expression of forkhead box protein A1 (FOXA1) and ubiquitin carboxy terminal hydrolase L1 (UCHL1) in lung squamous cell carcinoma (LSCC) tissues and clinicopathological parameters and prognosis. Methods: 100 LSCC patients who underwent surgical resection were selected, the expression of FOXA1 and UCHL1 in LSCC tissues and corresponding adjacent tissues was detected by immunohistochemistry. The relationship between the expression of FOXA1 and UCHL1 in LSCC tissues and clinicopathological parameters was analyzed, the overall survival (OS) and disease-free survival (DFS) curves of LSCC patients with positive/negative expression of FOXA1 and UCHL1 were drawn by Kaplan-Meier method. Results: Compared with adjacent tissues, the positive expression rates of FOXA1 and UCHL1 in cancer tissues were higher (P<0.05). The positive expression rates of FOXA1 and UCHL1 in LSCC tissues with different tumor size, differentiation degree, TNM stage and lymph node metastasis were different (P<0.05). The 3-year OS and DFS of 100 LSCC patients were 56.00% (56/100) and 49.00% (49/100) respectively. The 3-year OS and DFS of FOXA1 and UCHL1 positive expression patients were lower than those of FOXA1 and UCHL1 negative expression patients (P<0.05). Conclusion: The expression of FOXA1 and UCHL1 is up-regulated in LSCC tissues, which is closely related to poor prognosis. [ABSTRACT FROM AUTHOR]