肺鳞状细胞癌组织 PCBP1、GPSM2 表达与 EMT、临床病理特征 和预后的关系.

Objective: To explore the relationship between the expression of poly C binding protein-1 (PCBP1) and G-protein signaling modulator 2 (GPSM2) in lung squamous cell carcinoma tissue and epithelial mesenchymal transition (EMT), clinical pathological features, and prognosis. Methods: 80 patients with lung squamous cell carcinoma who underwent surgical resection in our hospital from January 2018 to June 2020 were selected as the study objects, analysis of the relationship between cancer tissue PCBP1, GPSM2, EMT markers, clinical pathological characteristics and prognosis in patients with lung squamous cell carcinoma tissue. Results: The positive expression rates of PCBP1, GPSM2 and E-cadherin in cancer tissues decreased compared to paracancer tissues, while the positive expression rate of vimentin was increased (P<0.05). The positive expression of PCBP and GPSM2 were negatively correlated with vimentin, and positively correlated with E-cadherin (P<0.05). The positive expression rates of PCBP1 and GPSM2 were correlated with low differentiation, TNM stage IIIA and lymph node metastasis (P<0.05). The survival rate of patients with positive expression of PCBP1 and GPSM2 is higher than that of patients with negative expression(P<0.05). Conclusion: The positive expression rates of PCBP1 and GPSM2 in cancer tissues of patients with lung squamous cell carcinoma decrease. The low expression of PCBP1 and GPSM2 is related to low differentiation, TNM stage IIIA, and lymph node metastasis, which can promote EMT of lung squamous cell carcinoma and lead to poor prognosis. [ABSTRACT FROM AUTHOR]