Subclinical variability in visual function modulates visual dependence - independent of age.

Paradoxically visual dependence is reported to increase with age, contributing to falls risk, whereas visual function typically declines. This study assesses the relationship between age, objective and subjective measures of visual function and visual dependence, in healthy young and older adults. Forty-four healthy Young (YA; n = 32; 18 males, aged 26.2 ± 5.3 yrs.) and Older (OA; n = 12; 3 males, aged 62.4 ± 6.7 yrs.) adults were assessed for objective (visual acuity, contrast sensitivity, depth perception, and lower peripheral vision), and subjective visual function (VFQ-25) along with motion sickness susceptibility. Subjective Visual Vertical (SVV) and induced nausea and vection were assessed using the Rod and Disc Test (RDT). Groups were compared using Mann-Whitney U, whilst determinants of SVV variability were evaluated using Multiple regression modelling. Visual acuity (p < 0.01) and contrast sensitivity (p = 0.04) were lower in OA. Visual dependence (SVV tilt errors) was not associated with ageing (p = 0.46). YA experienced greater RDT-induced vection (p = 0.03). Visual acuity and contrast sensitivity accounted for modest proportions of variance in SVV tilt errors (VA; R2 = 0.14, F(1,42) = 8.00, p < 0.01; β = 6.37) and (CS; R2 = 0.06, F(1,42) = 3.93, p = 0.05; β = −4.97), respectively. Our findings suggest that subclinical differences in visual acuity and contrast sensitivity contribute to SVV tilt error variability, among both healthy young and older adults. Further studies are needed to define the inter-relationship between age-related visual function, non-visual factors (including vestibular and somatosensory fidelity, activity levels, fear of falling and cognitive function) and visual dependence. Highlights: • Age alone was not a predictor of visual dependence in healthy individuals. • Visual acuity and contrast sensitivity were found to be lower in older adults. • There was no effect of age on vision-related health and quality of life • Variability in SVV tilt error was associated with sub-clinical differences in visual acuity and contrast sensitivity, rather than age alone. • There was an indirect effect of ageing on SVV tilt error, mediated by lower visual acuity and contrast sensitivity. [ABSTRACT FROM AUTHOR]