Alkaloids of a Cultivar of Catharanthus roseus, their Biological Activity, and Crystal Structures of Ajmalicine and Vindolinine.

The article discusses the alkaloid composition of Catharanthus roseus cultivated in Uzbekistan, highlighting the presence of ten indole monoterpenoid alkaloids. The study also includes the crystal structures of ajmalicine and vindolinine, the major alkaloids in C. roseus. Antimicrobial activity of the alkaloids was tested against various microorganisms, with vindolinine showing activity against Candida albicans and ajmalicine exhibiting antibacterial activity against Bacillus subtilis and Staphylococcus aureus. The research provides valuable insights into the alkaloid content and biological activity of C. roseus, contributing to the understanding of its potential medicinal applications. [Extracted from the article]