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Hernias and Ewing's sarcoma family of tumours: a pooled analysis and meta-analysis
- Source :
-
Lancet Oncology . Jul2005, Vol. 6 Issue 7, p485-490. 6p. - Publication Year :
- 2005
-
Abstract
- Summary: Background: Ewing''s sarcoma family of tumours has been associated with a history of hernia and with a parental occupation of farming. However, the causes of these tumours remain unknown. We therefore aimed to investigate the association between hernia and Ewing''s sarcoma family of tumours. Methods: We did a pooled analysis of two case-control studies and a meta-analysis of three case-control studies of Ewing''s sarcoma family of tumours that had adequate information on history of hernia. The primary endpoint was development of a tumour from the Ewing''s sarcoma family. 138 patients with such a tumour and 574 controls were included in the pooled analysis, and 357 patients with these tumours and 745 controls were included in the meta-analysis. Risk was assessed by an odds ratio (OR) and 95% CI by use of multivariate analysis with unconditional logistic regression for the pooled analysis and random effects model for the meta-analysis. Findings: Pooled analysis showed that children with Ewing''s sarcoma family of tumours were more likely to have had an umbilical hernia than were controls (odds ratio [OR] 3·3 [95% CI 1·3–8·0]). Meta-analysis showed that children with Ewing''s sarcoma family of tumours were more likely to have had a hernia (3·2 [1·9–5·7]). Interpretation: Ewing''s sarcoma family of tumours and hernias (particularly inguinal hernias) have common embryological pathways of neuroectodermal origin, and environmental factors, such as farming, might link the two entities. [Copyright &y& Elsevier]
- Subjects :
- *HERNIA
*EWING'S sarcoma
*OSTEOSARCOMA
*AGRICULTURE
*META-analysis
Subjects
Details
- Language :
- English
- ISSN :
- 14702045
- Volume :
- 6
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Lancet Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 18093476
- Full Text :
- https://doi.org/10.1016/S1470-2045(05)70242-4