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Neural Processing without O2 and Glucose Delivery: Lessons from the Pond to the Clinic.

Neural Processing without O2 and Glucose Delivery: Lessons from the Pond to the Clinic.

Authors :
Amaral-Silva, Lara
Santin, Joseph
Source :
Physiology. Nov2024, Vol. 39 Issue 6, p360-372. 13p.
Publication Year :
2024

Abstract

Neuronal activity requires a large amount of ATP, leading to a rapid collapse of brain function when aerobic respiration fails. Here, we summarize how rhythmic motor circuits in the brain stem of adult frogs, which normally have high metabolic demands, transform to produce proper output during severe hypoxia associated with emergence from hibernation. We suggest that general principles underlying plasticity in brain bioenergetics may be uncovered by studying nonmammalian models that face extreme environments, yielding new insights to combat neurological disorders involving dysfunctional energy metabolism. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15489213
Volume :
39
Issue :
6
Database :
Academic Search Index
Journal :
Physiology
Publication Type :
Academic Journal
Accession number :
180893812
Full Text :
https://doi.org/10.1152/physiol.00030.2023