Back to Search Start Over

Synthesis of Fused-Ring Pyrrolizine Derivatives via a Copper-Catalyzed Radical Cascade Cyclization.

Synthesis of Fused-Ring Pyrrolizine Derivatives via a Copper-Catalyzed Radical Cascade Cyclization.

Authors :
Xu, Xiao-Bo
Hao, Li-Qiang
Liu, Xian
Wang, Yang-Yang
Yang, Zhao-Zi-Yuan
Yu, Xiao
Ding, Dong
Ji, Ya-Fei
Source :
Synlett. Dec2024, Vol. 35 Issue 19, p2236-2240. 5p.
Publication Year :
2024

Abstract

Herein, an atom-economic method for the synthesis of fused-ring pyrrolizine derivatives by a cycloaddition reaction of easily accessible N -substituted pyrrole-2-carboxaldehydes with N -substituted maleimides in the presence of di- tert -butyl peroxide has been successfully developed. A total of 23 compounds were obtained by using this method, with a maximum yield of 72%, providing a practical and efficient method for the synthesis of tricyclic pyrrolizine frameworks. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09365214
Volume :
35
Issue :
19
Database :
Academic Search Index
Journal :
Synlett
Publication Type :
Academic Journal
Accession number :
180888129
Full Text :
https://doi.org/10.1055/a-2290-1682