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Synthesis of Fused-Ring Pyrrolizine Derivatives via a Copper-Catalyzed Radical Cascade Cyclization.
Synthesis of Fused-Ring Pyrrolizine Derivatives via a Copper-Catalyzed Radical Cascade Cyclization.
- Source :
-
Synlett . Dec2024, Vol. 35 Issue 19, p2236-2240. 5p. - Publication Year :
- 2024
-
Abstract
- Herein, an atom-economic method for the synthesis of fused-ring pyrrolizine derivatives by a cycloaddition reaction of easily accessible N -substituted pyrrole-2-carboxaldehydes with N -substituted maleimides in the presence of di- tert -butyl peroxide has been successfully developed. A total of 23 compounds were obtained by using this method, with a maximum yield of 72%, providing a practical and efficient method for the synthesis of tricyclic pyrrolizine frameworks. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MALEIMIDES
*RADICALS (Chemistry)
*RING formation (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 35
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 180888129
- Full Text :
- https://doi.org/10.1055/a-2290-1682