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Visible Light‐Driven Metal‐ and Photocatalyst‐Free Synthesis of β‐Trifluoromethylated Enamines via Trifluoromethyl Thianthrenium Salts.

Authors :
Jiang, Liang
Tang, Yisong
Li, Shaxuan
Peng, Xing
Saffar Andaloussi, Rim
Chen, Xiao Yun
Source :
Chemistry - An Asian Journal. Oct2024, p1. 9p. 8 Illustrations.
Publication Year :
2024

Abstract

A novel protocol for the visible‐light‐driven synthesis of β‐trifluoromethylated enamines has been developed, which operates without the use of transition metals or any photocatalysts, utilizing trifluoromethylthiosulfonium salts as the source of trifluoromethyl groups under mild conditions. According to this new protocol, more than 40 products have been prepared in moderate to good yields. In addition to eliminating the need for expensive or toxic transition metals and photocatalysts, this new methodology proves its potential scalability through air‐stability, the use of safe and readily available reagents, a two‐step one‐pot procedure, and effective gram‐scale reactions. This innovative approach not only demonstrates promise for green chemical synthesis but also offers a new pathway for the advancement of fluorine chemistry in sustainable organic synthesis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18614728
Database :
Academic Search Index
Journal :
Chemistry - An Asian Journal
Publication Type :
Academic Journal
Accession number :
180881794
Full Text :
https://doi.org/10.1002/asia.202401129