Are we approaching the development of a novel calcium phosphate-based bioceramic dental material?

Develop a sustainable bovine hydroxyapatite dental ceramic with the addition of titanium dioxide (TiO 2) nanoparticles (5 % and 8 % by weight), analyzing the outcome of this addition to the microstructure, as well as its mechanical and chemical properties, in order to evaluate whether they satisfy the International Organization for Standardization (ISO) 6872:2015 for dental ceramics or not. Disks were obtained through uniaxial followed by isostatic pressing from bovine hydroxyapatite powder and TiO 2 nanoparticles and sintered at 1300ºC for 2 h. Three experimental groups were developed (HA, HA+5 %TiO 2 and HA+8 %TiO 2) and subjected to X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), indentation fracture (IF), biaxial flexural strength (BFS) and chemical solubility test. XRD revealed, for HA group, the appearance of a peak corresponding to b-tricalcium phosphate (ß-TCP). For HA+ 5 %TiO 2 and HA+ 8 %TiO 2, the entire composition was converted into ß-TCP and calcium titanate (CaTiO 3). The SEM images showed a dense ceramic matrix and a uniform distribution of another phase in groups with TiO 2 nanoparticles. HA+ 5 %TiO 2 (1.40 ± 0.18 MPa.m1/2) and HA+ 8 %TiO 2 (1.32 ± 0.18 MPa.m1/2) showed significantly higher fracture toughness values than HA (0.67 ± 0.09 MPa.m1/2). HA showed significantly higher characteristic stress (295.8 MPa) in comparison to groups with 5 % (235.1 MPa) and 8 % (214.4 MPa) TiO 2 nanoparticles. Differences were not observed between the Weibull modulus values. The solubility results indicated that all experimental ceramics were above the 2000 ug/cm2 limit set by the ISO 6872:2015. This study proposed the development and characterization of a new ceramic for dental prosthesis made from HA extracted from bovine bones, with the intention of reusing these solids waste and transforming them into a sustainable and low-cost material. Although the experimental calcium phosphate ceramic with additions of 5 % and 8 % of TiO 2 achieved desirable mechanical properties, the chemical solubility values were very high. [Display omitted] • Bovine HA derived bioceramic with TiO 2 presents sustainability potential. • The addition of 5 % and 8 %TiO 2 significantly improved material's fracture toughness. • HA + TiO 2 bioceramic material converted microstructure to ß-TCP and CaTiO 3. • HA+TiO 2 achieved mechanical ISO standards, but failed chemical solubility limits. [ABSTRACT FROM AUTHOR]