DR SPUR'S MYSTERY CASE: HSV -- can it be a clue to an underlying inborn error of immunity?

The article in the journal "Current Allergy & Clinical Immunology" discusses a case of a 54-year-old man with herpes simplex virus (HSV) type-1 encephalitis and raises the question of whether inborn errors of immunity could be associated with severe viral infections like HSV-1 encephalitis. It highlights the role of genetic factors in severe viral infections and the importance of considering underlying inborn errors of immunity in patients with severe, persistent, unusual, or recurrent viral infections. The article emphasizes the need for a high level of clinical suspicion and appropriate laboratory workup to identify potential genetic susceptibilities to viral infections. [Extracted from the article]