Synthesis and Characterization of 1,2-Dihydroquinoline Sulphonamides: Novel Derivatives with Enhanced Pharmacological Potential.

The present investigation reports the synthesis and characterization of a novel series of 1,2-dihydroquinoline sulphonamides, developed with the aim of enhancing their pharmacological efficacy. The synthesis involved a multi-step process starting with the preparation of 3-hydroxy Acetanilide, followed by Pechmann condensation to obtain acetylated aminophenol, and subsequent reactions leading to the formation of 1,2-dihydroquinoline derivatives. These derivatives were further reacted with various substituted sulphonyl chlorides to yield the target sulphonamide compounds. The synthesized compounds were characterized using FTIR, 1H NMR, 13C NMR, and LCMS. Their pharmacological activities, including antibacterial, anthelmintic, anti-inflammatory, and antihyperlipidemic properties, were evaluated through in-vitro assays. The results demonstrated that these novel 1,2-dihydroquinoline sulphonamides exhibit promising pharmacological activities, validating their potential as effective therapeutic agents. [ABSTRACT FROM AUTHOR]