The Relationship Between Intraindividual Sleep-Wake Variability and Mental Health in Adolescents.

ObjectiveMethodsResultsConclusionWe investigated the relationship between irregular sleep-wake patterns and other aspects of sleep and mental health among adolescents.Community-based sample of adolescents (<italic>n</italic> = 200, mean age 16.8; 61.7% female) completed baseline assessment (i.e. sleep quality, daytime sleepiness, depressive symptoms, social anhedonia, problematic alcohol use), and 7–8 consecutive days of wearing wrist actigraphy. Irregular sleep-wake patterns were assessed via two methods, both based on actigraphy, to capture day-to-day irregularity (intraindividual variability, IIV) and weekly irregularity (social jet lag, SJL). The Bayesian variability method was performed to calculate IIV in total sleep time (TST), sleep onset, and offset time. SJL was quantified as the actual difference in the sleep midpoint on school days versus non-school days.Greater IIV in TST was associated with poorer sleep quality (B = 1.66, 95% CI, 0.14, 3.31, <italic>p</italic> < .05), and greater depressive symptoms (B = 0.72, 95% CI, 0.17, 1.35, <italic>p</italic> < .05), while greater IIV in sleep offset time was associated greater depressive symptoms (B = 0.63, 95% CI, 0.03, 1.28, <italic>p</italic> < .05), and greater problematic alcohol use (B = 0.70, 95% CI, 0.12, 1.35, <italic>p</italic> < .05), all after adjusting for age, sex, family SES, alcohol drinks, and SJL. No significant association was found with sleep onset time. Greater SJL was associated with poorer sleep quality (B = 0.40, 95% CI, 0.27, 0.54, <italic>p</italic> < .001) and fewer problematic alcohol uses (B = −0.05, 95% CI, −0.09, −0.00, <italic>p</italic> < .05), when adjusting for age, sex, family SES, and alcohol drinks.Our findings add to a growing body of research on irregularity in sleep-wake patterns and clinical implications. [ABSTRACT FROM AUTHOR]