Impacts of post‐operation loading and fixation implant on the healing process of fractured tibia.

Healing of tibia demonstrates a complex mechanobiological process as it is stimulated by the major factor of strains applied by body weight. The effect of screw heads and bodies as well as their pressure distribution is often overlooked. Hence, effective mechanical conditions of the healing process of tibia can be categorized into the material of the plate and screws, post‐operation loadings, and screw type and pressure. In this paper, a mathematical biodegradation model was used to simulate the PGF/PLA plate‐screw device over 8 weeks. The effect of different post‐operation loading patterns was studied for both locking and non‐locking screws. The aim was to reach the best configuration for the most achievable healing using FEA by computing the healing pattern, trend, and efficiency with the mechano‐regulation theory based on deviatoric strain. The biodegradation process of the plate and screws resulted in 82% molecular weight loss and 1.05 GPa decrease in Young's modulus during 8 weeks. The healing efficiency of the cases ranged from 4.72% to 14.75% in the first week and 18.64% to 63.05% in the eighth week. Finally, an optimal case was achieved by considering the prevention of muscle erosion, bone density reduction, and nonunion, according to the obtained results. [ABSTRACT FROM AUTHOR]