DSP-01 conversion from PLS to ALS: a Dutch cohort study.

Authors :: McFarlane, R.
Domhnaill, É.M.
Al-Chalabi, A.
van den Berg, L.
de Carvalho, M.
Chio, A.
Corcia, P.
van Damme, P.
McDermott, C.
Ingre, C.
Povedanos, M.
Galvin, M.
Hardiman, O.
Ciepielewska, M.
Chandak, A.
Khachatryan, A.
Lavu, A.
Silva, P.D.
Novak, J.C.
Zhang, J.
Source :: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2024 Suppl 1, Vol. 25, p262-279. 18p.
Publication Year :: 2024
Abstract: The document delves into multiple studies on Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration, focusing on topics such as disease diagnosis, patient stratification, and understanding disease mechanisms. It discusses the importance of biomarkers, autonomic nervous function, and astrocyte pathology in ALS research and clinical trials. Additionally, the research explores genetic risk factors, respiratory impairments, and the impact of genetic polymorphisms on survival in ALS and FTD patients, aiming to improve prognosis and management of these neurodegenerative diseases. [Extracted from the article]