Therapeutic prospects of sex hormone receptor signaling in hormone-responsive cancers.

Globally, hormone-responsive cancers afflict millions of people contributing to cancer-related morbidity and mortality. While hormone-responsive cancers overburden patients, their close families, and even health budgets at the local levels, knowledge of these cancers particularly their biology and possible avenues for therapy remains poorly exploited. Herewith, this review highlights the role of sex hormones (estrogens and androgens) in the pathophysiology of hormone-responsive cancers and the exploration of therapeutic targets. Major scientific databases including but not limited to Scopus, PubMed, Science Direct, Web of Science core collections, and Google Scholar were perused using a string of search terms: Hormone-responsive cancers, androgens and cancers, estrogens and cancer, androgen receptor signalling, estrogen receptor signalling, etc. [Display omitted] • Sex hormone receptor signaling is implicated in hormone-responsive cancers. • Andro-estrogen receptor signaling influence complexities of hormone-responsive cancers. • Upstream and downstream targets of andro-estrogen receptor signaling provide a repertoire of avenues for therapeutic strategies against hormone-responsive cancers. [ABSTRACT FROM AUTHOR]