血清 ApoA1、ApoB、Hcy 水平与高血压合并 冠心病的相关性.

Objective To investigate the correlation of serum apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and homocysteine (Hcy) levels with hypertension complicating coronary heart disease (CHD) . Methods We selected 156 cases including patients with essential hypertension (EH), hypertensives with CHD who had undergone coronary CT or coronary angiography (CAG), and healthy physical examinees. They were divided into four groups: EH group (n = 61), EH accompanied with stable angina pectoris (SAP) group (EH+SAP group, n = 29), EH complicating acute coronary syndrome (ACS) group (EH+ACS group, n = 32), and healthy physical examinees (control group, n = 34). We detected blood lipids and Hcy levels of the enrolled subjects in each group, and evaluated the changes of ApoA1, ApoB and Hcy levels in patients with single, double and multi-vessel lesions. The Gensini scores of patients with hypertension complicating CHD were calculated according to coronary CT or CAG results. The correlation of serum ApoA1, ApoB and Hcy levels with hypertension complicating CHD was explored by Logistic regression analysis. Results There were no statistically significant differences in age, sex, BMI, smoking history and drinking history among the four groups (all P>0. 05). The levels of ApoB and Hcy in the EH+SAP group and the EH+ACS group were all higher than those in the EH group and the control group (P< 0. 05), while the level of ApoA1 was the opposite. Binary multivariate Logistic regression analysis showed that ApoA1, ApoB and Hcy were all risk factors for hypertension complicating CHD. The higher the Gensini score and the number of diseased vessels were, the lower the level of ApoA1 was, indicating a negative correlation between them; the higher the Gensini score and the number of diseased vessels were, the higher the levels of ApoB and Hcy were, indicating a positive correlation between them, and the differences were all statistically significant (all P<0. 05). Conclusion ApoA1, ApoB and Hcy could be used as risk factors for hypertension complicating CHD, and could predict the severity of coronary artery disease to a certain extent. They could provide references for the prevention and treatment of the disease together with low- and high-density lipoprotein, and other traditional indexes of blood lipids. [ABSTRACT FROM AUTHOR]