Systematic review – Adjuvant radiotherapy of the vulva in primary vulvar cancer.

Adjuvant radiotherapy to the vulva in vulvar squamous cell carcinoma (VSCC) is frequently performed albeit strong evidence is lacking. This systematic review aims to summarize the current literature on this topic. 19 retrospective studies were included and analyzed, focusing on the primary outcome of local recurrence. The publications present conflicting results. While the benefit of adjuvant radiotherapy to the groins in case of node-positive VSCC is well established, the indication criteria and effectiveness of adjuvant radiotherapy to the vulva remain unclear. Based on the studies included in this review, the current evidence suggests that adjuvant radiotherapy to the vulva might not significantly reduce the risk of recurrence or only in certain subgroups. Most of the studies do not consider individual risk factors such as HPV status, resection margin, lymph node stage, grading and others. As a result, the comparability and reliability of these findings are limited. This review aims to highlight the need of further research addressing the risk stratification, considering both oncologic risk factors and adverse events. • Indication criteria are controversial as potential prognostic factors are not consistently considered across studies. • Lymph node status is the most important prognostic factor and should trigger discussion about adjuvant local treatment. • Future studies should aim to differentiate subgroups and stratify patients according to risk factors such as HPV. [ABSTRACT FROM AUTHOR]