Efficacy of internet-based cognitive behavioral and interpersonal treatment for depression in Arabic speaking countries: A randomized controlled trial.

Politically and economically unstable contexts have been associated with increased prevalence rates of depression. Despite high demand, the availability of mental health experts and care systems is limited in Arabic-speaking countries. Internet-based interventions might provide an opportunity to treat patients independently of location. Therefore, we investigated the efficacy of internet-based cognitive behavioral treatment (iCBT) and interpersonal treatment (iIPT) for depression in Arabic-speaking countries. In total, 743 Arabic-speaking adults with depression were randomly allocated to iCBT (n = 243), iIPT (n = 247), or waitlist (n = 253). Depressive, anxiety, and somatoform symptoms, perceived social support and quality of life (QoL) were assessed at pre-, and post-treatment and at three months follow-up. Multiple imputation was performed for missing data. Changes associated with treatment were analyzed using regression in the completer and intention-to-treat sample. Participants in both treatment groups showed lower depressive and anxiety symptom severity, higher QoL, and perceived social support compared to the waitlist group (p <.001). Somatoform symptom severity was significantly lower in participants receiving iIPT compared to waitlist (p <.001). Differences between the two treatments in all outcomes were non-significant (p >.05). Three-month follow-up treatment effects regarding depressive symptoms were indicated. The sample mainly consists of educated, single, female adults. Three-month follow-up results rely on a small subsample and must be interpreted with caution. This is the first randomized controlled trial to demonstrate the efficacy of iCBT and iIPT for depression in Arabic-speaking countries. It provides first indications that internet-based interventions might help specific individuals in this region. • Internet.based interventions seem to be effective in reducing depressive symptoms for people in Arabic-speaking countries. • Internet-based cognitive behavioral and interpersonal treatment seems to be equally effective in reducing depressive symptoms. • Both internet-based interventions, designed for people with depression, increase QoL and perceived social support from different sources. • Dropout rates in both interventions are similarly high. • Overall treatment satisfaction was high. [ABSTRACT FROM AUTHOR]