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The effect of melatonin and probiotics on radiation-induced enteritis in experimental rat models.
- Source :
-
Radiation Effects & Defects in Solids: Incorporating Plasma Techniques & Plasma Phenomena . Nov2024, p1-15. 15p. 4 Illustrations. - Publication Year :
- 2024
-
Abstract
- Radiotherapy plays an important role in the treatment of tumors, and enteritis is a common side effect of this therapy. The aim of present study was to evaluate the protective effect of melatonin and probiotics on radiation-induced intestinal tissue damage in rats. Histopathological, biochemical and microbiological samples were examined.Thirty-two Wistar Albino rats were randomly distributed into four groups: the control group, only radiotherapy (RT) group, radiotherapy plus melatonin (RT + MEL) groups and radiotherapy plus probiotics (RT + PROB) groups. The abdominal-pelvic region of the experimental rat was irradiated with in a single dose of 16 Gy. The melatonin was administered at a single dose of 50 mg/kg through intraperitoneal injection, 15 min before radiation exposure. The probiotic was administered orally every day to the rats for 5 days starting before radiotherapy.There was a statistically significant changes in histopathological (villus atrophy, mitotic activity, apoptotic index, goblet cell swelling, degenerative changes, atypia) and biochemical (oxidant and antioxidant status, IL-1β, IL-6 and TNF- α levels) parameters in the small intestine in the radiotherapy group G2 compared to the G1 control group (<italic>p</italic> < 0.05). However, a significant decrease was observed with the administration of probiotics and melatonin (<italic>p</italic> < 0.05). In addition, although positive bacterial growth was detected in the mesenteric lymph node of all rats in the radiotherapy group, there was no statistically significant difference between all groups (<italic>p</italic> > 0.05).Melatonin and probiotics were found to have a potent radioprotective effect against radiotherapy-induced acute small intestinal tissue damage. However, their superiority over each other was not observed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10420150
- Database :
- Academic Search Index
- Journal :
- Radiation Effects & Defects in Solids: Incorporating Plasma Techniques & Plasma Phenomena
- Publication Type :
- Academic Journal
- Accession number :
- 180670092
- Full Text :
- https://doi.org/10.1080/10420150.2024.2424751